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Premium Isoxanthohumol (CAS 521-48-2) | 98%+ HPLC Purity | Anticancer & Antiviral Flavonoid
Isoxanthohumol is a bioactive prenylflavonoid primarily derived from hops (Humulus lupulus) and beer. This potent compound exhibits significant antiproliferative effects against multiple human cancer cell lines and inhibits metastatic tumor development in vivo. It also demonstrates broad-spectrum antiviral activity against herpes viruses (HSV1/HSV2) and bovine viral diarrhea virus (BVDV), making it a valuable candidate for pharmaceutical and nutraceutical research.
Product Name :
IsoxanthohumolCAS No. :
521-48-2Appearance :
Yellow crystalline powderSpecification :
98%CAS No.: 521-48-2 | Molecular Formula: C??H??O? | MW: 354.4
Appearance: Pale yellow crystalline powder
Botanical Source: Humulus lupulus (Hops)
Bioactive Estrogen Modulator & Metabolic Optimizer
≥98% Pure: Pharma-grade crystalline powder (HPLC/UV verified)
5%-50% Blends: Cost-effective for mass-market supplements
Liquid Formulations: Ethanol-soluble for beverages/topical serums
? Hormonal Balance
Converts to 8-Prenylnaringenin (8-PN) in vivo; alleviates menopausal hot flashes (+37% efficacy vs placebo, J. Menopausal Med. 2022)
? Anticancer Activity
Inhibits breast/prostate cancer cell proliferation via ERβ/AR modulation and NF-κB pathway suppression
? Metabolic Health
Reduces hepatic lipid accumulation by activating AMPK; improves glucose uptake in 2D/3D cell models
? Antioxidant Protection
Scavenges 92% of free radicals (ORAC assay); protects skin from UV-induced collagen degradation
| Parameter | Detail |
|---|---|
| Purity | ≥98% (HPLC-DAD, λ=280nm) |
| Solubility | DMSO, ethanol, PEG-400; insoluble in water |
| Melting Point | 172-174°C |
| Storage | -20°C, desiccated, protected from light |
| Shelf Life | 24 months |
| Heavy Metals | <5 ppm (USP/EP) |
| ?? Pharmaceuticals | ?? Cosmeceuticals | ?? Functional Foods |
|---|---|---|
| • Menopausal symptom management | • Anti-aging creams (boosts SIRT1) | • Estrogen-balancing beverages |
| • Breast cancer chemoprevention | • UV-protective serums | • Metabolic health supplements |
| • NAFLD/NASH therapeutic adjuncts | • Antioxidant ampoules | • Hops-infused energy drinks |
?? Patented Extraction
Supercritical CO? isolation (yield >92%, solvent-free) from organic German Hallertau hops
?? Bioavailability Enhancement
Custom lipid nanoparticles (LNPs) for 3.2x oral absorption (vs. raw powder)
?? Certified Quality
ISO 9001, Non-GMO Project Verified
| Quantity | Packaging | Delivery Time |
|---|---|---|
| 1g–100g | Amber glass vials + argon sealing | 3-7 days (DHL) |
| 100g–5kg | Foil bags in vacuum-sealed tubs | 5-10 days (Air) |
| >5kg | Food-grade drums (N? flushed) | 15-30 days (Sea) |
Q: Does conversion to 8-PN occur in humans?
A: Yes, confirmed by urinary metabolite studies (up to 32% conversion rate with enteric coating).
Q: MOQ for bulk orders?
A: 100g for ≥98% purity; 1kg for blends.
Q: Stability in liquid formulations?
A: 12-month stability in ethanol/PG solutions (pH 5–7, protected from light).
Q: Documentation for FDA submissions?
A: Full DMF Type II available upon request.
Q: Synergistic formulations?
A: Pre-developed complexes with resveratrol (breast health) and genistein (bone density).
Derived from hops (Humulus lupulus), 8-Prenylnaringenin (8-PN) is a potent phytoestrogen with selective estrogen receptor modulator (SERM) activity, offering superior efficacy compared to soy isoflavones for alleviating menopausal symptoms like hot flashes and promoting bone health while supporting muscle maintenance without exercise through Akt pathway regulation.
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Sourced from Humulus lupulus L. (hops), our Xanthohumol is a potent prenylated flavonoid, renowned for its high bioactivity and role as the primary active compound in hops extracts. Available in multiple purity grades (1%, 5%, 10%, and 98%) to suit diverse industrial needs, with high-purity variants exhibiting a bright yellow crystalline appearance
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Isoxanthohumol is a bioactive prenylflavonoid primarily derived from hops (Humulus lupulus) and beer. This potent compound exhibits significant antiproliferative effects against multiple human cancer cell lines and inhibits metastatic tumor development in vivo. It also demonstrates broad-spectrum antiviral activity against herpes viruses (HSV1/HSV2) and bovine viral diarrhea virus (BVDV), making it a valuable candidate for pharmaceutical and nutraceutical research.
Read More
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